This is the gold-standard, definitive test for diagnosing Systemic Lupus Erythematosus (SLE). It is a highly specific blood test that detects antibodies in your blood that are attacking your body's own DNA. Its presence is a hallmark of Lupus. Furthermore, the level (titre) of this antibody is a critical, quantitative tool your doctor uses to monitor your disease activity and your response to treatment. This test is essential if your initial ANA screen is positive. A simple blood draw provides the conclusive, specific answer your doctor needs to move from symptoms to a clear diagnosis and an effective management plan.